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ELANZA Wellness Ltd have taken all reasonable steps to ensure that the information provided on this communication is accurate at the time of writing. However, it may vary at the time of further enquiry due to supplier variations and is subject to change.  This content is not a substitute for professional medical advice. It does not create a doctor-patient relationship, nor is it a solicitation to offer medical advice. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. 

RESOURCES: FACTS & FIGURES

Men in their fifties have reduced success in fertility treatment

Bionews

The chance of success with fertility treatment using IVF or ICSI decreases if a man is over 51, according to a new study. The analysis, of nearly 5000 IVF/ICSI cycles, suggested that this was the case regardless of the woman's age. 'There may well be a public perception that male fertility is independent of age,' said Dr Guy Morris from the Centre for Reproductive and Genetic Health (CRGH) in London, where the retrospective study was carried out. 'Stories of celebrity men fathering children into their 60s may give a skewed perspective on the potential risks of delaying fatherhood.'

Air pollution reduces women's egg reserves

Bionews

Exposure to environmental air pollutants may decrease a woman's ovarian reserve, suggests a new study. 'Living in an area associated with high levels of air pollutants in our study increased the risk of severely reduced ovarian reserve by a factor of two or three,' said Professor Antonio La Marca from the University of Modena and Reggio Emilia in Modena, Italy.

Women find egg freezing emotionally challenging, DMU research finds

De Montfort University Leicester (DMU)

Research by De Montfort University Leicester (DMU) has shown that women who freeze their eggs are more likely to find the procedure emotionally challenging than other fertility patients. A paper recently published in Human Fertility by Dr Kylie Baldwin and Professor Lorraine Culley of the Centre for Reproduction Research at De Montfort University found that women who freeze their eggs find the procedure particularly emotionally challenging often due to the fact that they are undergoing the technology without the support of a partner.

I.V.F. Does Not Raise Breast Cancer Risk, Study Shows

NY Times

Women undergoing in vitro fertilization have long worried that the procedure could raise their risk for breast cancer. After all, the treatment requires temporarily increasing levels of certain sex hormones to five or 10 times the normal. Two of those hormones, estrogen and progesterone, can affect the course of certain kinds of breast cancer. A series of studies over the past decade suggested that these former patients may have little to worry about.

What Fertility Patients Should Know About Egg Freezing

New York Times

The failure of systems used to store frozen eggs and embryos at two fertility clinics has rattled people who count on such clinics to help them realize their hopes of having children. But the breakdowns at clinics in Cleveland and San Francisco, each apparently involving the temperature or level of liquid nitrogen in one storage tank, have damaged at least some eggs and embryos belonging to potentially hundreds of people. At a time when egg freezing is increasing swiftly — some Silicon Valley companies now tout it as a perk for their employees — the incidents raise questions about what to look for and ask if you are considering taking that step. Here is a basic guide:

Egg Freezing Success Rates

Southern California Reproductive Center (SCRC)

What factors affect egg freezing success rates? When you start looking at the numbers, the first step is to make sure you know which success metric you’re looking at. Successful thawing rates, fertilization rates, pregnancy rates, and live birth rates are all very different things. All of these data points are useful, but it’s important to compare apples with apples. Since the main goal of egg freezing is to hopefully come home with a healthy baby when it’s time to start your family, we’ll look at live birth rates. Even restricting the definition to live birth rates varies on how that number is calculated. The numbers you see published can have a huge range, anywhere from 2% to 40% or more. This is usually because they are measuring different things. The commonly seen 2% to 12% success rate often used to discredit egg freezing is per egg retrieved, using the older freezing methods. Using new, advanced vitrification freezing methods gives numbers more like 4% to 14% per egg retrieved. When you multiply those percentages by the number of eggs frozen, the picture starts to look a lot rosier. There are also many other variables which can make a huge difference in the live-birth success rates: Age at time of egg freezing and number of eggs frozen As with most things fertility-related, age is at the top of the list. In short, the younger a woman is when she freezes her eggs, the higher the likelihood that using those eggs will result in pregnancy and live birth. This is because egg quality drops as women age, and young women in their 20s are more likely to produce a larger number of higher quality eggs in a given egg freezing cycle. That means that when it’s time to use the eggs, there are more chances for success. No matter where a woman is in her reproductive years, the number of eggs she chooses to freeze clearly affects the final chances of pregnancy, by virtue of simple math: more eggs = more opportunities, and the chance for doctors to choose the highest quality, strongest embryos to transfer.

Optimal Timing for Elective Egg Freezing: REPORT

American Society for Reproductive Medecine

Oocyte cryopreservation provided the greatest improvement in probability of live birth compared with no action (51.6% vs. 21.9%) when performed at age 37 years. The highest probability of live birth was seen when oocyte cryopreservation was performed at ages <34 years (>74%), although little benefit over no action was seen at ages 25–30 years (2.6%–7.1% increase). Oocyte cryopreservation was most cost-effective at age 37 years, at $28,759 per each additional live birth in the oocyte cryopreservation group. When the probability of marriage was included, oocyte cryopreservation resulted in little improvement in live birth rates.

EggBanxx estimates that 76,000 women will be freezing their eggs by 2018

TIME

Egg-freezing is taking off among professional women. Doctors say they’ve seen more interest in the procedure since Apple and Facebook announced last year they’d cover egg-freezing in their employee health plans, and younger women are beginning to ask about how they can preserve their fertility. In 2009, only about 500 women froze their eggs—in 2013, almost 5,000 did, according to data obtained from the Society for Assisted Reproductive Technology (SART.) Fertility marketer EggBanxx estimates that 76,000 women will be freezing their eggs by 2018.

From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies

PMC

Human in vitro fertilization (IVF) as a treatment for infertility is regarded as one of the most outstanding accomplishments of the 20th century, and its use has grown dramatically since the late 1970s. Although IVF is considered safe and the majority of children appear healthy, reproductive technologies have been viewed with some skepticism since the in vitro environment deviates substantially from that in vivo. This is increasingly significant because the Developmental Origins of Health and Disease (DOHaD) hypothesis has illuminated the sensitivity of an organism to its environment at critical stages during development, including how suboptimal exposures restricted specifically to gamete maturation or the preimplantation period can affect postnatal growth, glucose metabolism, fat deposition, and vascular function. Today, some of the physiological metabolic phenotypes present in animal models of IVF have begun to emerge in human IVF children, but it remains unclear whether or not in vitro embryo manipulation will have lasting health consequences in the offspring. Our expanding knowledge of the DOHaD field is fueling a paradigm shift in how disease susceptibility is viewed across the life course, with particular emphasis on the importance of collecting detailed exposure information, identifying biomarkers of health, and performing longitudinal studies for any medical treatment occurring during a developmentally vulnerable period. As IVF use continues to rise, it will be highly valuable to incorporate DOHaD concepts into the clinical arena and future approaches to public health policy.

The State of Fertility Report

Healthline

The U.S. birth rate hit an all-time low in 2016 as the number of women under age 30 having children fell. Yet, more women over 30, especially between 40 and 44 years old, are having children. The changing cultural norms, trends in postponing parenthood, and increasingly sophisticated fertility treatments may be creating a misconception — one that’s devastating for many — that becoming a mother later in life is easy. By pulling together several expert interviews, a new Healthline survey of 1,214 people, and Healthline’s proprietary search and social data, we’ve developed a comprehensive overview of the current fertility landscape. In this report, Healthline explores how American parenthood is drastically changing — and how it will continue to evolve over the next few years.

The Costs of Egg Freezing

FertilityIQ

In the US, An average egg freezing cycle, which consists of hormone stimulation, egg retrieval, and lab processing, costs around $16,000. Your clinic will likely charge you $11,000 and the medication will cost around $5,000. Below are average costs broken down by city, including medication and 5 years of storage.

SART 2016 IVF Success Rate Report

SART

This report captures the treatment burden to the patient (the number of cycles) as well as the best outcome (delivery of a healthy child) by tracking outcomes over time for an individual, accounting for both fresh and frozen embryo transfers.

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